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Exploring the association between microbiota and behavior in suckling piglets


  • Collins, SM, Surette, M. & Bercik, P. The interplay between the intestinal microbiota and the brain. Nat. Rev. Microbiol. 10735–742 (2012).

    CAS PubMed Article Google Scholar

  • De Palma, G., Collins, SM, Bercik, P. & Verdu, EF The microbiota–gut–brain axis in gastrointestinal disorders: Stressed bugs, stressed brain or both?. J. Physiol. 5922989–2997 (2014).

    PubMed PubMed Central Article CAS Google Scholar

  • Sherwin, E., Bordenstein, SR, Quinn, JL, Dinan, TG & Cryan, JF Microbiota and the social brain. Science (80-). 366(2019).

  • Valles-Colomer, M. et al. The neuroactive potential of the human gut microbiota in quality of life and depression. Nat. Microbiol. 4623–632 (2019).

    CAS PubMed Article Google Scholar

  • Johnson, KVA & Foster, KR Why does the microbiome affect behaviour?. Nat. Rev. Microbiol. 16647–655 (2018).

    CAS PubMed Article Google Scholar

  • Well done, HA et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. proc. Natl. Acad. Sci USA 10816050–16055 (2011).

    ADS CAS PubMed PubMed Central Article Google Scholar

  • Davidson, GL, Cooke, AC, Johnson, CN & Quinn, JL The gut microbiome as a driver of individual variation in cognition and functional behaviour. Philos. Trans. R. Soc. B Biol. Sci. 373(2018).

  • Ezenwa, VO, Gerardo, NM, Inouye, DW, Medina, M. & Xavier, JB Animal behavior and the microbiome. Science (80-). 338198–199 (2012).

    ADS CAS Article Google Scholar

  • Cryan, JF & Dinan, TG Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour. Nat. Rev. Neurosci. 13701–712 (2012).

    CAS PubMed Article Google Scholar

  • Dobbing, J. & Sands, J. Comparative aspects of the brain growth spurt. Early Hum. Dev. 379–83 (1979).

    CAS PubMed Article Google Scholar

  • Conrad, MS & Johnson, RW The domestic piglet: An important model for investigating the neurodevelopmental consequences of early life insults. Annu. Rev. Anime. Biosci. 3245–264 (2015).

    CAS PubMed Article Google Scholar

  • Nguyen, TLA, Vieira-Silva, S., Liston, A. & Raes, J. How informative is the mouse for human gut microbiota research?. DMM Dis. Model. Mech. 81–16 (2015).

    CAS PubMed Article Google Scholar

  • Verbeek, E., Keeling, L., Landberg, R., Lindberg, JE & Dicksved, J. The gut microbiota and microbial metabolites are associated with tail biting in pigs. Sci.Rep. eleven1–14 (2021).

    Article CAS Google Scholar

  • hey y et al. Exploring the role of gut microbiota in host feeding behavior among breeds in swine. BMC Microbiol. 221–15 (2022).

    CAS PubMed PubMed Central Article Google Scholar

  • Parois SP, Eicher SD, Lindemann SR & Marchant JN Potential improvements of the cognition of piglets through a synbiotic supplementation from 1 to 28 days via the gut microbiota. Sci.Rep. eleven1–15 (2021).

    Article CAS Google Scholar

  • Choudhury, R. et al. Early life feeding accelerates gut microbiome maturation and suppresses acute post-weaning stress in piglets. Environment. microbiol. 00(2021).

  • Choudhury, R. et al. Impact of early-life feeding on local intestinal microbiota and digestive system development in piglets. Sci.Rep. eleven1–16 (2021).

    Article CAS Google Scholar

  • Hessing, MJC, Hagelsø, AM, Schouten, WGP, Wiepkema, PR & Van Beek, JAM Individual behavioral and physiological strategies in pigs. Physiol. Behav. 5539–46 (1994).

    CAS PubMed Article Google Scholar

  • Zebunke, M., Nürnberg, G., Melzer, N. & Puppe, B. The backtest in pigs revisited—Inter-situational behavior and animal classification. App. anime Behav. Sci. 1947–13 (2017).

    ArticleGoogle Scholar

  • Bolhuis, JE, Parmentier, HK, Schouten, WGP, Schrama, JW & Wiegant, VM Effects of housing and individual coping characteristics on immune responses of pigs. Physiol. Behav. 79289–296 (2003).

    CAS PubMed Article Google Scholar

  • Düpjan, S., Schön, PC, Puppe, B., Tuchscherer, A. & Manteuffel, G. Differential vocal responses to physical and mental stressors in domestic pigs (sus scrofa). App. anime Behav. Sci. 114105–115 (2008).

    ArticleGoogle Scholar

  • Manteuffel, G., Puppe, B. & Schön, PC Vocalization of farm animals as a measure of welfare. App. anime Behav. Sci. 88163–182 (2004).

    ArticleGoogle Scholar

  • Fraser, D. Vocalizations of isolated piglets. I. Sources of variation and relationships among measures. App. anime Ethol. 1387–394 (1975).

    ArticleGoogle Scholar

  • Fraser, D. The vocalizations and other behavior of growing pigs in an ‘open field’ test. App. anime Ethol. 13–16 (1974).

    ArticleGoogle Scholar

  • Reimert, I., Rodenburg, TB, Ursinus, WW, Kemp, B. & Bolhuis, JE Responses to novel situations of female and castrated male pigs with divergent social breeding values ​​and different backtest classifications in barren and straw-enriched housing. App. anime Behav. Sci. 15124–35 (2014).

    ArticleGoogle Scholar

  • Donald, RD, Healy, SD, Lawrence, AB & Rutherford, KMD Emotionality in growing pigs: Is the open field a valid test?. Physiol. Behav. 104906–913 (2011).

    CAS PubMed Article Google Scholar

  • Ursinus, W.W. et al. Relations between peripheral and brain serotonin measures and behavioral responses in a novelty test in pigs. Physiol. Behav. 11888–96 (2013).

    CAS PubMed Article Google Scholar

  • Andersen, IL, Færevik, G., Bøe, KE, Janczak, AM & Bakken, M. Effects of diazepam on the behavior of weaned pigs in three putative models of anxiety. App. anime Behav. Sci. 68121–130 (2000).

    CAS PubMed Article Google Scholar

  • Bailey, MT et al. Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation. Brain. Behav. Immun. 25397–407 (2011).

    CAS PubMed Article Google Scholar

  • DePalma, G. et al. Microbiota and host determinants of behavioral phenotype in maternally separated mice. Nat. Commun. 67735 (2015).

    ADS PubMed Article CAS Google Scholar

  • Simpson CA, Mu A, Haslam N, Schwartz OS & Simmons JG Feeling down? A systematic review of the gut microbiota in anxiety/depression and irritable bowel syndrome. J. Affect. Disord. 266429–446 (2020).

    CAS PubMed Article Google Scholar

  • Cussotto, S. et al. Differential effects of psychotropic drugs on microbiome composition and gastrointestinal function. Psychopharmacology 2361671–1685 (2019).

    CAS PubMed Article Google Scholar

  • Forkman, B., Boissy, A., Meunier-Salaün, MC, Canali, E. & Jones, RB A critical review of fear tests used on cattle, pigs, sheep, poultry and horses. Physiol. Behav. 92340–374 (2007).

    CAS PubMed Article Google Scholar

  • Clouard, C., Gerrits, WJ, van Kerkhof, I., Smink, W. & Bolhuis, JE Dietary linoleic and α-linolenic acids affect anxiety-related responses and exploratory activity in growing pigs. J. Nutr. 145358–364 (2015).

    PubMed Article CAS Google Scholar

  • Backus, BL, Sutherland, MA & Brooks, TA Relationship between environmental enrichment and the response to novelty in laboratory-housed pigs. J.Am. Assoc. Lab. Anime. Sci. 56735–741 (2017).

    PubMed PubMed Central Google Scholar

  • Iversen, MW et al. Heritability of the backtest response in piglets and its genetic correlations with production traits. Animal eleven556–563 (2017).

    CAS PubMed Article Google Scholar

  • Velie, BD, Maltecca, C. & Cassady, JP Genetic relationships among pig behavior, growth, backfat, and loin muscle area. J. Anim. Sci. 872767–2773 (2009).

    CAS PubMed Article Google Scholar

  • Zebunke, M., Repsilber, D., Nürnberg, G., Wittenburg, D. & Puppe, B. The backtest in pigs revisited—An analysis of intra-situational behaviour. App. anime Behav. Sci. 16917–25 (2015).

    ArticleGoogle Scholar

  • Bolhuis, JE, Schouten, WGP, Leeuw, JAD, Schrama, JW & Wiegant, VM Individual coping characteristics, rearing conditions and behavioral flexibility in pigs. Behav. Brain Res. 152351–360 (2004).

    PubMed ArticleGoogle Scholar

  • Bolhuis, JE, Schouten, WGPP, Schrama, JW & Wiegant, VM Behavioral development of pigs with different coping characteristics in barren and substrate-enriched housing conditions. App. anime Behav. Sci. 93213–228 (2005).

    ArticleGoogle Scholar

  • Kanitz, E. et al. Coping style of pigs is associated with different behavioral, neurobiological and immune responses to stressful challenges. Front. Behav. Neurosci. 131–15 (2019).

    Article CAS Google Scholar

  • Middlekoop, A. et al. Effects of creep feed provision on behavior and performance of piglets around weaning. Front. Vet. Sci. 7879 (2020).

    ArticleGoogle Scholar

  • Yu, Z. & Morrison, M. Improved extraction of PCR-quality community DNA from digesta and fecal samples. Biotechniques 36808–812 (2004).

    CAS PubMed Article Google Scholar

  • Quast, C. et al. The SILVA ribosomal RNA gene database project: Improved data processing and web-based tools. Nucleic Acids Res. 41590–596 (2013).

    Article CAS Google Scholar

  • ter Braak, CJF & Smilauer, P. Canoco Reference Manual and User’s Guide: Software for Ordination, Version 5.0. (MicrocomputerPower, 2012).

  • Morgan, XC et al. Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biol. 13(2012).



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